- IN STOCK
- product code: V004
Recombinant VWF-A3 domain, residues 1683-1874, human.
The protein contains a N-terminal his tag and is produced in HEK293E cells and purified to homogeneity.
Human Von Willebrand Factor (VWF) is a multimeric glycoprotein, which is involved in binding coaggulaion factor VIII and in adhesion of platelets at sites of vascular damage. In this process the VWF-A3 domain binds to collagen in the vascular matrix.
Reference sequences: NM_000552, NP_000543, Swiss-prot P04275.
Alternative names: Von Willebrand antigen II, Von Willebrand Factor, F8VW.F
Gene ID: 7450
Residues 1683-1874 of human VWF were cloned, the protein was over-expressed and was purified to homogeneity. The calculated molecular weight of recombinant human VWF-A3 domain is 20.5 kDa. Each vial contains 100 µg VWF-A3 at 0.43 mg/ml. The proteins contains a N-terminal, trombin cleavable, hexahistidine tag.