Recombinant VWF-A1 domain, residues 1261-1468,VWD type 2B, human.

100 microgram.

The protein contains a N-terminal his tag and is produced in HEK293E cells and purified to homogeneity.

Human Von Willebrand Factor (VWF) is a multimeric glycoprotein, which is involved in binding coaggulaion factor VIII and in adhesion of platelets at sites of vascular damage. In this process the platelet receptor glycoprotein Ib-IX-V complex binds to the VWF-A1 domain. The VWF-A1 variant in this product contains Von Willebrand Disease type 2B mutation R1306Q, which induces spontaneous binding of the VWF-A1 domain to platelet receptor GpIb-IX-V complex.

Reference sequences: NM_000552, NP_000543, Swiss-prot P04275.

Alternative names: Von Willebrand antigen II, Von Willebrand Factor, F8VWF.

Gene ID: 7450.

Residues 1261-1468 of human VWF containing mutation R1306Q were cloned, the protein was over-expressed and was purified to homogeneity (figure 1). The calculated molecular weight of recombinant human VWF-A1 domain is 23.8 kDa. Each vial contains 100 µg VWF-A1 at 8.14 mg/ml.

Download the product data sheet of the current lot, lot 553.

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