- IN STOCK
- product code: T006
Recombinant Thrombomodulin-(TEV-his)N, human.
The protein contains a N-terminal, TEV-protease cleavable his tag and is produced in HEK293E cells and purified to homogeneity.
This glycoprotein is an endothelial-specific type I membrane receptor that binds thrombin in a 1:1 stoichiometry. This binding results in the activation of protein C, which degrades coaggulation factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Reference sequences: NM_000361, NP_000352, Swiss-prot P07204.
Alternative names: CD141, fetomodulin, TFPI.
Gene ID: 7056
The mature protein of human thrombomodulin, residues 19 - 516 was over-expressed in HEK293EBNA1 cells and purified to homogeneity. The protein has 5 potential N-linked glycosylation sites and 2 potential O-linked glycosylation sites. The protein contains a N-terminal TEV protease cleavable hexahistidine tag. The calculated molecular weight without glycosylation of recombinant human thrombomodulin-(his-TEV)C, residues 19 - 516 including hexahistidine tag, is 54.9 kDa. Each vial contains 100 µg Thrombomodulin-(his-TEV)N at 1.84 mg/ml.