Product description:
Human ACE-2 (angiotensin-converting enzyme 2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angioten- kDa sin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). The protein is produced in HEK293 cells and contains a C-terminal, TEV-protease cleavable Fc-tag. It was purified to homogeneity (figure 1). The calculated molecular weight of recombinant hACE-2-(TEV-Fc)C is 193.9 kDa.